Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719504 | 0.68 | HSD11B1 (0.47) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL22342839 | 0.67 | CYP2C9 (0.47) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20819792 | 0.67 | CYP2C9 (0.47) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL22319459 | 0.67 | CYP2C9 (0.43) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6923510 | 0.67 | POLB (0.49) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL6923507 | 0.67 | POLB (0.49) | NPBWR1HSD11B1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL14640465 | 0.67 | KAT2B (0.47) | NPBWR1ALDH1A1HTTPIK3CBPIK3CA | |
| SCHEMBL22342841 | 0.66 | ALDH1A1 (0.46) | HSD11B1CYP2C9CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL25276584 | 0.66 | HSD11B1 (0.57) | HSD11B1CYP2C9CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL25276585 | 0.66 | HSD11B1 (0.57) | HSD11B1CYP2C9CYP2C19ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293374-A1 | Substituted isothiazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293374-A1 | Substituted isothiazolones | LTB4R2, PTGES2, CYSLTR2 | NPBWR1 1919/4885HSD11B1 250/4885CYP2C9 1862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.