Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 9/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | IDE | P14735 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241023 | 0.80 | POLB (0.46) | NPC1RAB9APRKD1CHRM3TP53 | |
| SCHEMBL12241028 | 0.75 | NPC1 (0.47) | NPC1RAB9APRKD1TP53MAPT | |
| SCHEMBL14641595 | 0.72 | POLB (0.39) | CHRM3TP53MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL12241027 | 0.71 | POLB (0.46) | NPC1RAB9ACHRM3TP53MAPT | |
| SCHEMBL14641757 | 0.68 | F10 (0.39) | NPC1RAB9ATP53 | |
| SCHEMBL12241032 | 0.68 | POLB (0.46) | PRKD1CHRM3TP53MAPTPOLB | |
| SCHEMBL14641589 | 0.66 | MET (0.49) | CHRM3SMN1; SMN2POLB | |
| SCHEMBL12241256 | 0.65 | POLB (0.47) | PRKD1CHRM3TP53RAD52GALK1 | |
| SCHEMBL30685779 | 0.63 | TSHR (0.48) | KDM4EMAPK1ALDH1A1POLB | |
| SCHEMBL14641558 | 0.63 | NPC1 (0.46) | NPC1RAB9ATP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |