Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981975 | 0.90 | MET (0.51) | METNQO2SMN1; SMN2CHRM3AVPR1B | |
| SCHEMBL12265755 | 0.81 | MET (0.48) | METNQO2BRD4POLB | |
| SCHEMBL14641595 | 0.78 | POLB (0.39) | SMN1; SMN2ROCK2CHRM3POLB | |
| SCHEMBL12265753 | 0.75 | MET (0.47) | METNQO2POLBMAP4K4 | |
| SCHEMBL13981879 | 0.75 | ACHE (0.37) | ACHE | |
| SCHEMBL22309754 | 0.74 | MET (0.58) | METNQO2SMN1; SMN2ACHE | |
| SCHEMBL12266108 | 0.74 | MET (0.47) | METNQO2POLBMAP4K4 | |
| SCHEMBL1296276 | 0.74 | MET (0.57) | METNQO2CHRM3ACHE | |
| SCHEMBL12266116 | 0.73 | MET (0.49) | METNQO2POLB | |
| SCHEMBL31495087 | 0.72 | MET (0.57) | METNQO2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |