Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 2/20 | 0.37 |
| ▸ | PTAFR | P25105 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174445 | 0.94 | ERN1 (0.44) | ERN1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL22103530 | 0.83 | ERN1 (0.39) | ERN1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL24313743 | 0.79 | HTR2A (0.42) | ERN1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL20789986 | 0.77 | PDGFRB (0.42) | PDGFRBPDGFRAPDE4BPDE4APDE4C | |
| SCHEMBL2964491 | 0.76 | ALDH1A1 (0.53) | PDGFRBPDGFRAPDE4BPDE4APDE4C | |
| Formic Acid SCHEMBL28266826 | 0.76 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DTSHR | |
| SCHEMBL9188312 | 0.73 | NR3C1 (0.60) | PDE4BPDE4APDE4CPDE4DQDPR | |
| SCHEMBL31528141 | 0.73 | QDPR (0.40) | PDGFRBPDGFRAPDE4BPDE4APDE4C | |
| SCHEMBL24313632 | 0.72 | CYP11B1 (0.43) | PDE4BPDE4DLMNATSHRALDH1A1 | |
| SCHEMBL21986515 | 0.72 | ALDH1A1 (0.38) | LMNAALDH1A1KDM4ETDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354402-B2 | Polyarylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-01-15 | — | — | US | disclosed |