SCHEMBL1464299

SCHEMBL1464299

Cc1ccc(S(=O)(=O)C(C)(C)C(=O)O)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 1/20 0.41
KAT6A Q92794 3/20 0.38
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
METAP2 P50579 2/20 0.37
MEP1B Q16820 2/20 0.37
GAA P10253 1/20 0.36
CYP2C9 P11712 2/20 0.36
TSHR P16473 2/20 0.35
LMNA P02545 1/20 0.35
NAMPT P43490 1/20 0.34
ALOX15 P16050 1/20 0.34
ABCC9 O60706 1/20 0.34
ABCC8 Q09428 1/20 0.34
KCNJ11 Q14654 1/20 0.34
KCNJ8 Q15842 1/20 0.34
PIK3C3 Q8NEB9 1/20 0.34
TTR P02766 1/20 0.33
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10171693 0.85 CES2 (0.40) ALDH1A1HPGDHSD17B10GAALMNA
SCHEMBL16502025 0.83 ALDH1A1 (0.49) CSNK2A1ALDH1A1HPGDHSD17B10MEP1B
SCHEMBL1465565 0.82 ALDH1A1 (0.48) ALDH1A1TSHRLMNASMN1; SMN2
SCHEMBL1464788 0.80 KAT6A (0.45) KAT6AMEP1BGAACYP2C9TSHR
SCHEMBL1465570 0.77 KAT6A (0.45) KAT6ATSHRALOX15ABCC9ABCC8
SCHEMBL14664317 0.77 KAT6A (0.35) KAT6AALDH1A1HPGDMEP1BGAA
SCHEMBL1464221 0.75 RIPK1 (0.40) KAT6AALDH1A1HPGDHSD17B10MEP1B
SCHEMBL10171221 0.75 CNR1 (0.35) KAT6AALDH1A1MEP1BGAALMNA
SCHEMBL29385904 0.74 KAT6A (0.40) CSNK2A1KAT6AALDH1A1HSD17B10MEP1B
SCHEMBL3163671 0.74 KAT6A (0.40) CSNK2A1KAT6AALDH1A1HSD17B10MEP1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8299111-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-10-30 US disclosed
US-8299111-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-10-30 US disclosed
US-8299111-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-10-30 US disclosed
EP-2081905-B1 SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INT (DE) 2012-09-12 EP disclosed
US-7935715-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-03 US disclosed
US-7935715-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-03 US disclosed
US-7935715-B2 Compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-03 US disclosed
US-20110071127-A1 Compounds Which Modulate the CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 US disclosed
US-20110071127-A1 Compounds Which Modulate the CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 US disclosed
US-20110071127-A1 Compounds Which Modulate the CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 US disclosed
US-20080039464-A1 Compounds Which Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-14 US disclosed
US-20080039464-A1 Compounds Which Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080039464-A1 Compounds Which Modulate The CB2 Receptor CNR2, CNR1, OPRL1 CSNK2A1 616/4885KAT6A 2256/4885ALDH1A1 2360/4885
US-20110071127-A1 Compounds Which Modulate the CB2 Receptor CNR2, CNR1, OPRL1 CSNK2A1 627/4885KAT6A 2289/4885ALDH1A1 2203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.