Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14643309 | 0.79 | MLKL (0.41) | CYP1A2ALOX15ALDH1A1HTTMEN1 | |
| SCHEMBL311171 | 0.77 | KDM4E (0.41) | ALOX15ALDH1A1HTTKDM4ECDK9 | |
| SCHEMBL311312 | 0.77 | KDM4E (0.41) | ALOX15ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL1490778 | 0.74 | NUDT1 (0.42) | ALOX15ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL14644491 | 0.74 | KDM4E (0.39) | ALOX15ALDH1A1HTTKDM4ECDK9 | |
| SCHEMBL6514887 | 0.74 | CYP1A2 (0.44) | CYP1A2ALOX15ALDH1A1HTTMEN1 | |
| SCHEMBL202410 | 0.74 | KDM4E (0.40) | CYP1A2ALOX15ALDH1A1HTTKDM4E | |
| SCHEMBL30445736 | 0.71 | CYP1A2 (0.39) | CYP1A2ALOX15ALDH1A1HTTMEN1 | |
| SCHEMBL204605 | 0.71 | CSNK2A1 (0.39) | ALOX15ALDH1A1HTTKDM4ECDK9 | |
| SCHEMBL2086309 | 0.71 | KDM4E (0.39) | ALOX15ALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007768-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |