Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14643309 | 0.74 | MLKL (0.41) | CYP1A2ALDH1A1ALOX15MEN1HTT | |
| SCHEMBL14643308 | 0.71 | CYP1A2 (0.39) | CYP1A2ALDH1A1ALOX15MEN1HTT | |
| SCHEMBL31295918 | 0.69 | PARP1 (0.41) | PARP1 | |
| SCHEMBL25294421 | 0.69 | PARP1 (0.41) | PARP1 | |
| SCHEMBL12424042 | 0.69 | JAK1 (0.46) | CYP1A2JAK1AXL | |
| SCHEMBL20283374 | 0.69 | JAK1 (0.46) | CYP1A2JAK1AXL | |
| SCHEMBL10769866 | 0.68 | RAB9A (0.47) | ALDH1A1MEN1KMT2AJAK1ADORA2B | |
| SCHEMBL3552668 | 0.65 | PDPK1 (0.58) | MEN1KMT2AADORA2AADORA1PDPK1 | |
| SCHEMBL6515025 | 0.63 | CYP1A2 (0.53) | CYP1A2ALDH1A1ALOX15MEN1HTT | |
| SCHEMBL15668178 | 0.63 | PDPK1 (0.39) | MEN1KMT2AADORA2AADORA1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12150943-B2 | JAK1 pathway inhibitors for the treatment of gastrointestinal disease | INCYTE CORPORATION (US) | 2024-11-26 | — | — | US | disclosed |
| US-20230172939-A1 | JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF GASTROINTESTINAL DISEASE | INCYTE CORPORATION | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230172939-A1 | JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF GASTROINTESTINAL DISEASE | JAK1, JAK3, JAK2 | CYP1A2 2630/4885ALDH1A1 1842/4885ALOX15 1098/4885 |
| US-12150943-B2 | JAK1 pathway inhibitors for the treatment of gastrointestinal disease | JAK1, JAK3, JAK2 | CYP1A2 2630/4885ALDH1A1 1842/4885ALOX15 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.