Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14644369 | 0.92 | ADK (0.41) | ADKABL1RIN1PRMT5WDR77 | |
| SCHEMBL31154632 | 0.83 | ADORA3 (0.56) | ADKPRMT5WDR77ADORA3ADORA2A | |
| SCHEMBL15960600 | 0.83 | ADORA3 (0.56) | ADKPRMT5WDR77ADORA3ADORA2A | |
| SCHEMBL14644657 | 0.81 | ADK (0.47) | ADKABL1RIN1PRMT5WDR77 | |
| SCHEMBL15960616 | 0.80 | ADK (0.44) | ADKPRMT5WDR77ADORA3CSF1R | |
| SCHEMBL31170878 | 0.79 | ADK (0.46) | ADKADORA3ADORA2A | |
| SCHEMBL14643921 | 0.79 | PRMT5 (0.38) | ADKPRMT5WDR77ADORA3RET | |
| SCHEMBL15960613 | 0.78 | ADK (0.43) | ADKABL1RIN1ADORA3CSF1R | |
| SCHEMBL18490461 | 0.78 | ADK (0.48) | ADKADORA3ADORA2A | |
| SCHEMBL18490545 | 0.78 | ADK (0.48) | ADKADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013009735-A1 | 5'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | WO | disclosed |