Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14645383 | 0.82 | PTPN11 (0.44) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL26992265 | 0.81 | EPHX2 (0.41) | KMT2AMEN1RAB9AALDH1A1APP | |
| SCHEMBL30693907 | 0.81 | ALDH1A1 (0.49) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL14645321 | 0.81 | EPHX2 (0.46) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL22495331 | 0.79 | PKM (0.62) | ALDH1A1TSHRTP53L3MBTL1 | |
| SCHEMBL31502389 | 0.78 | PLA2G4B (0.47) | ALDH1A1TSHRMMP2MMP9MMP8 | |
| SCHEMBL29262374 | 0.78 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL31503058 | 0.77 | MAPT (0.57) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL19332007 | 0.77 | HDAC3 (0.47) | NPC1RAB9ASMN1; SMN2TP53PPARA | |
| SCHEMBL16561515 | 0.77 | GAA (0.59) | RAB9AALDH1A1SMN1; SMN2PPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729178-A1 | TYROSINE LIGATION PROCESS | Novartis AG (CH) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013009564-A1 | TYROSINE LIGATION PROCESS | NOVARTIS AG (CH) | 2013-01-17 | — | — | WO | disclosed |