Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19332006 | 1.00 | HDAC3 (0.47) | HDAC3HDAC2HDAC8NCOR2RAD51 | |
| SCHEMBL19331876 | 0.85 | RAB9A (0.51) | HDAC3HDAC2HDAC8NCOR2RAD51 | |
| SCHEMBL19332281 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AMAPTTP53NPC1 | |
| SCHEMBL3462941 | 0.81 | EGFR (0.66) | EGFRSMN1; SMN2RAB9AMAOBMAPT | |
| SCHEMBL3462939 | 0.81 | EGFR (0.66) | EGFRSMN1; SMN2RAB9AMAOBMAPT | |
| SCHEMBL7138298 | 0.79 | THRB (0.56) | HDAC3HDAC2HDAC8NCOR2SMN1; SMN2 | |
| SCHEMBL30069269 | 0.79 | THRB (0.56) | HDAC3HDAC2HDAC8NCOR2SMN1; SMN2 | |
| SCHEMBL2040098 | 0.77 | KMT2A (0.65) | SMN1; SMN2RAB9AMAPT | |
| SCHEMBL14645191 | 0.77 | KMT2A (0.44) | SMN1; SMN2RAB9AMAPTTP53NPC1 | |
| SCHEMBL27403959 | 0.77 | ALDH1A1 (0.63) | EGFRSMN1; SMN2MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11801315-B2 | Radioligands for myelin | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-10-31 | — | — | US | disclosed |
| US-20230201382-A1 | RADIOLIGANDS FOR MYELIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-29 | — | — | US | disclosed |
| EP-3426309-B1 | RADIOLIGANDS FOR MYELIN | UNIV CASE WESTERN RESERVE (US) | 2022-05-04 | — | — | EP | disclosed |
| US-20210128756-A1 | RADIOLIGANDS FOR MYELIN | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-05-06 | — | — | US | disclosed |
| US-10765763-B2 | Radioligands for myelin | CASE WESTERN RESERVE UNIVERSITY (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190134232-A1 | RADIOLIGANDS FOR MYELIN | CASE WESTERN RESERVE UNIVERSITY | 2019-05-09 | — | — | US | disclosed |
| EP-3426309-A1 | RADIOLIGANDS FOR MYELIN | Case Western Reserve University (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017156303-A1 | RADIOLIGANDS FOR MYELIN | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134232-A1 | RADIOLIGANDS FOR MYELIN | MAG, PMP22, MYT1 | HDAC3 2057/4885HDAC2 3424/4885HDAC8 2976/4885 |
| US-20230201382-A1 | RADIOLIGANDS FOR MYELIN | MAG, PMP22, MYT1 | HDAC3 2573/4885HDAC2 3183/4885HDAC8 3630/4885 |
| US-20210128756-A1 | RADIOLIGANDS FOR MYELIN | MAG, PMP22, MYT1 | HDAC3 2057/4885HDAC2 3424/4885HDAC8 2976/4885 |
| US-11801315-B2 | Radioligands for myelin | MAG, PMP22, MYT1 | HDAC3 2057/4885HDAC2 3424/4885HDAC8 2976/4885 |
| US-10765763-B2 | Radioligands for myelin | MAG, PMP22, MYT1 | HDAC3 2057/4885HDAC2 3424/4885HDAC8 2976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.