SCHEMBL14645246

SCHEMBL14645246

NC(=O)N(C(N)=O)[C@@H](CSSC[C@H](N)C(=O)O)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 7/20 0.40
NOS1 P29475 5/20 0.40
NOS3 P29474 4/20 0.40
ARG1 P05089 1/20 0.37
ARG2 P78540 1/20 0.37
ALOX15 P16050 2/20 0.35
KMT2A Q03164 2/20 0.35
BLM P54132 1/20 0.35
PMP22 Q01453 1/20 0.35
PTGS1 P23219 1/20 0.34
SLC7A11 Q9UPY5 1/20 0.34
GRIK1 P39086 2/20 0.34
GRIK2 Q13002 2/20 0.34
GRM1 Q13255 2/20 0.34
GRM2 Q14416 2/20 0.34
ALDH1A1 P00352 1/20 0.34
KIF11 P52732 2/20 0.33
MEN1 O00255 1/20 0.33
CYP2C19 P33261 1/20 0.33
SLC7A5 Q01650 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14645245 1.00 NOS2 (0.40) NOS2NOS1NOS3ARG1ARG2
SCHEMBL14645243 1.00 NOS2 (0.40) NOS2NOS1NOS3ARG1ARG2
SCHEMBL9433207 0.87 ARG1 (0.38) NOS2NOS1NOS3ARG1ARG2
SCHEMBL111220 0.84 NOS2 (0.42) NOS2NOS1NOS3ARG1ARG2
SCHEMBL111218 0.84 NOS2 (0.42) NOS2NOS1NOS3ARG1ARG2
SCHEMBL7773882 0.84 NOS2 (0.42) NOS2NOS1NOS3ARG1ARG2
SCHEMBL111219 0.84 NOS2 (0.42) NOS2NOS1NOS3ARG1ARG2
Hydrochloric Acid SCHEMBL28613072 0.82 NOS2 (0.41) NOS2NOS1NOS3ARG1ARG2
SCHEMBL25177325 0.81 GRIK1 (0.35) NOS2NOS1NOS3ARG1ARG2
SCHEMBL21979221 0.81 GRIK1 (0.35) NOS2NOS1NOS3ARG1ARG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9549964-B2 Diagnosis, prognosis, and treatment of kidney disease BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2017-01-24 US disclosed
US-20140228296-A1 DIAGNOSIS, PROGNOSIS, AND TREATMENT OF KIDNEY DISEASE BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2014-08-14 US disclosed
WO-2013010085-A2 DIAGNOSIS, PROGNOSIS, AND TREATMENT OF KIDNEY DISEASE BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2013-01-17 WO disclosed