Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14647203 | 0.86 | CHRM2 (0.38) | MEN1KMT2AGRIA2HTR1AHTR1D | |
| SCHEMBL1338153 | 0.83 | LMNA (0.37) | HTR1AHTR1DHTR1FPIK3CBPIK3CG | |
| SCHEMBL565648 | 0.83 | LMNA (0.37) | HTR1AHTR1DHTR1FPIK3CBPIK3CG | |
| SCHEMBL22226792 | 0.79 | USP30 (0.41) | MEN1KMT2AHTR1AHTR1DHTR1F | |
| SCHEMBL12129039 | 0.78 | HTR1A (0.32) | HTR1AHTR1DHTR1FAVPR1AAVPR1B | |
| SCHEMBL7906093 | 0.78 | HTR1A (0.32) | HTR1AHTR1DHTR1FAVPR1AAVPR1B | |
| SCHEMBL31392972 | 0.75 | MAPT (0.41) | MEN1KMT2AHTR1AHTR1DHTR1F | |
| SCHEMBL16440168 | 0.74 | AAK1 (0.43) | — | |
| SCHEMBL2018716 | 0.73 | HTR2C (0.47) | — | |
| SCHEMBL692930 | 0.73 | HTR2C (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373649-B1 | INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-01-23 | — | — | EP | disclosed |