Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 5/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648552 | 0.88 | CYP2C9 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL12438588 | 0.88 | CYP1A2 (0.71) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL26762358 | 0.84 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL26765183 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL26639245 | 0.82 | RAB9A (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL29527371 | 0.82 | RAB9A (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL12439117 | 0.82 | BRS3 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL2990343 | 0.81 | RAB9A (0.77) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL26762361 | 0.80 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL9784679 | 0.80 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176892-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD. (CN) | 2016-06-23 | — | — | US | disclosed |
| US-9315513-B2 | Benzimidazole derivatives and their pharmaceutical compositions and uses | Xuanzhu Pharma Co., Ltd. (CN) | 2016-04-19 | — | — | US | disclosed |
| US-20130023568-A1 | Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses | Xuanzhu Pharma Co., Ltd. (CN) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176892-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES | F12, HRH2, H1-3 | CYP1A2 311/4885CYP3A4 47/4885CYP2D6 152/4885 |
| US-20130023568-A1 | Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses | F12, HRH2, H1-3 | CYP1A2 311/4885CYP3A4 47/4885CYP2D6 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.