Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15443876 | 0.79 | GNAI3 (0.33) | TSHR | |
| SCHEMBL15443877 | 0.76 | L3MBTL3 (0.33) | TSHR | |
| SCHEMBL14654986 | 0.75 | MAPK1 (0.41) | — | |
| SCHEMBL15443892 | 0.75 | TSHR (0.30) | TSHR | |
| SCHEMBL15443900 | 0.75 | ACHE (0.33) | TSHR | |
| SCHEMBL14655015 | 0.73 | MAPK1 (0.43) | — | |
| SCHEMBL15443801 | 0.72 | TSHR (0.37) | TSHR | |
| SCHEMBL15443901 | 0.71 | CHRM1 (0.35) | — | |
| SCHEMBL19981483 | 0.71 | EBP (0.35) | — | |
| SCHEMBL15443760 | 0.71 | MEN1 (0.41) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2013012752-A2 | METHODS AND COMPOSITIONS FOR MANIPULATING TRANSLATION OF PROTEIN ISOFORMS FROM ALTERNATIVE INITIATION START SITES | SAREPTA THERAPEUTICS, INC. (US) | 2013-01-24 | — | — | WO | disclosed |