Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 6/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679783 | 0.84 | BACE1 (0.59) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL3716080 | 0.82 | MAP4K4 (0.49) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL18761580 | 0.82 | ALDH1A1 (0.49) | ADORA2AADORA1CACNA1BMEN1ALDH1A1 | |
| SCHEMBL15844149 | 0.81 | CACNA1B (0.53) | ADORA2AADORA1CACNA1BALDH1A1PGR | |
| Bromide SCHEMBL118833 | 0.81 | MAP4K4 (0.48) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL14655355 | 0.81 | HTR3E (0.42) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| Bromide SCHEMBL2380345 | 0.81 | MAP4K4 (0.48) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL5679441 | 0.81 | MASP2 (0.47) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| Bromide SCHEMBL2379661 | 0.80 | HTR3E (0.41) | HTR3EHTR3BHTR3ABACE1HTR3D | |
| SCHEMBL117352 | 0.80 | BACE1 (0.54) | HTR3EHTR3BHTR3ABACE1HTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | claimed |
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2549874-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2013-01-30 | — | — | EP | disclosed |