Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 7/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.42 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | SGK1 | O00141 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696797 | 0.85 | MAPK1 (0.56) | MAPK1AXLCAMKK2DHODHLDHA | |
| SCHEMBL14655364 | 0.85 | MAPK1 (0.40) | MAPK1DHODHCYP2C9SYKJAK3 | |
| SCHEMBL14655368 | 0.84 | AXL (0.47) | MAPK1AXLDHODHCYP2C9SYK | |
| SCHEMBL14655266 | 0.82 | ACMSD (0.43) | MAPK1CYP2C9SYKJAK3JAK2 | |
| SCHEMBL28813690 | 0.81 | MAPK1 (0.71) | MAPK1DHODHCYP2C9SYK | |
| SCHEMBL14795215 | 0.81 | MAPK1 (0.49) | MAPK1LDHALDHBCYP2C9SYK | |
| SCHEMBL14655604 | 0.81 | MAPK1 (0.39) | MAPK1AXLCYP2C9SYKJAK3 | |
| SCHEMBL14655425 | 0.80 | CCR1 (0.47) | MAPK1AXLCYP2C9SYKJAK3 | |
| SCHEMBL14655380 | 0.80 | JAK3 (0.41) | MAPK1CYP2C9SYKJAK3JAK2 | |
| SCHEMBL14655643 | 0.80 | SORT1 (0.42) | MAPK1DHODHCYP2C9SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| CN-102803265-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2012-11-28 | — | — | CN | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| CN-102803265-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2012-11-28 | — | — | CN | disclosed |