Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 10/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655572 | 0.86 | ERCC1 (0.38) | MAPK1SYKCYP2C9JAK3JAK2 | |
| SCHEMBL14655366 | 0.81 | MAPK1 (0.47) | MAPK1SYKCYP2C9JAK3JAK2 | |
| SCHEMBL14655368 | 0.78 | AXL (0.47) | MAPK1KDM4EPOLBSYKCYP2C9 | |
| SCHEMBL14655643 | 0.77 | SORT1 (0.42) | MAPK1ALDH1A1HPGDSYKCYP2C9 | |
| SCHEMBL14655425 | 0.77 | CCR1 (0.47) | MAPK1KDM4EALDH1A1POLBHPGD | |
| SCHEMBL14655380 | 0.77 | JAK3 (0.41) | MAPK1SYKCYP2C9JAK3JAK2 | |
| SCHEMBL14655475 | 0.76 | KDM4C (0.43) | MAPK1KDM4ESYKCYP2C9JAK3 | |
| SCHEMBL12300102 | 0.76 | JAK1 (0.45) | JAK3JAK2JAK1 | |
| SCHEMBL14797172 | 0.75 | PHF8 (0.50) | MAPK1SYKJAK3JAK2JAK1 | |
| SCHEMBL14655364 | 0.75 | MAPK1 (0.40) | MAPK1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |