Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KDM5C | P41229 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068867 | 0.87 | CDK8 (0.53) | KDM4CKDM5BKDM5ACDK8SYK | |
| SCHEMBL14655380 | 0.81 | JAK3 (0.41) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL14655425 | 0.81 | CCR1 (0.47) | KDM4CSYKCYP2C9KDM4EKDM5C | |
| SCHEMBL14655366 | 0.79 | MAPK1 (0.47) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL14655643 | 0.78 | SORT1 (0.42) | SYKCYP2C9JAK3MAPK1 | |
| SCHEMBL14655368 | 0.77 | AXL (0.47) | KDM4CKDM5BSYKCYP2C9KDM4E | |
| SCHEMBL14655604 | 0.76 | MAPK1 (0.39) | SYKCYP2C9KDM4EJAK3JAK2 | |
| SCHEMBL14795215 | 0.76 | MAPK1 (0.49) | CDK8SYKCYP2C9JAK3MAPK1 | |
| SCHEMBL12301302 | 0.76 | JAK2 (0.47) | JAK3JAK2JAK1 | |
| SCHEMBL14655300 | 0.76 | SYK (0.59) | SYKCYP2C9JAK3ROCK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| CN-102803265-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2012-11-28 | — | — | CN | disclosed |