Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118039 | 0.92 | CHRNB2 (0.46) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| Silicate SCHEMBL11242395 | 0.89 | HPGD (0.40) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| Butadiene SCHEMBL4458837 | 0.84 | HPGD (0.41) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| Styrene SCHEMBL4895288 | 0.82 | ALDH1A1 (0.54) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| Styrene SCHEMBL693301 | 0.82 | ALDH1A1 (0.54) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7939095 | 0.82 | HPGD (0.41) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5406615 | 0.82 | ACHE (0.35) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| Acrylonitrile SCHEMBL8754554 | 0.78 | CHRNB2 (0.37) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3693208 | 0.74 | MAOB (0.44) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19010026 | 0.73 | CHRNB2 (0.39) | HPGDCHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2736529-A2 | STABILIZED FORMULATIONS CONTAINING ANTI-PCSK9 ANTIBODIES | Regeneron Pharmaceuticals, Inc. (US) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013016648-A2 | STABILIZED FORMULATIONS CONTAINING ANTI-PCSK9 ANTIBODIES | REGENERON PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |