Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11599668 | 0.86 | ALDH1A1 (0.67) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL11681237 | 0.84 | KLK7 (0.44) | ALDH1A1CYP3A4SMN1; SMN2RECQLLMNA | |
| SCHEMBL29094176 | 0.84 | KLK7 (0.44) | ALDH1A1CYP3A4SMN1; SMN2RECQLLMNA | |
| SCHEMBL27632520 | 0.83 | ALDH1A1 (0.68) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL10368135 | 0.83 | KLK7 (0.43) | ALDH1A1CYP3A4SMN1; SMN2RECQLCYP2C19 | |
| SCHEMBL750021 | 0.82 | ALDH1A1 (0.61) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL14662860 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL13158231 | 0.81 | ALDH1A1 (0.69) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL14663002 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 | |
| SCHEMBL9474373 | 0.81 | ALDH1A1 (0.64) | ALDH1A1CYP3A4SMN1; SMN2RECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734519-B1 | ANTI-BIOFILM COMPOUNDS | UNIV LOUISVILLE RES FOUND (US) | 2016-05-04 | — | — | EP | disclosed |
| EP-2734519-B1 | ANTI-BIOFILM COMPOUNDS | UNIV LOUISVILLE RES FOUND (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| EP-2734519-A1 | ANTI-BIOFILM COMPOUNDS | University Of Louisville Research Foundation, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013016206-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2013016206-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | MSR1, NPR1, FPR1 | ALDH1A1 3602/4885CYP3A4 3902/4885SMN1; SMN2 4826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.