SCHEMBL146603

SCHEMBL146603

O=[C]Cc1cccc2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.52
CYP2C19 P33261 2/20 0.52
CYP2C9 P11712 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
ACP3 P15309 1/20 0.50
CYP2D6 P10635 2/20 0.48
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
CA2 P00918 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
MTNR1A P48039 1/20 0.43
CTNNB1 P35222 1/20 0.43
NQO2 P16083 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2325052 0.88 HPRT1 (0.52) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL1611986 0.83 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL2858432 0.82 CYP1A2 (0.56) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL2858430 0.82 CYP1A2 (0.56) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL2326627 0.82 ALDH1A1 (0.42) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL143127 0.80 MTNR1A (0.46) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL143457 0.79 MTNR1A (0.49) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL182660 0.78 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL6176844 0.78 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9TDP1ACP3
SCHEMBL7033804 0.78 CYP1A2 (0.57) CYP1A2CYP2C19CYP2C9TDP1ACP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2296 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240158441-A1 BRANCHED PEPTIDES FOR ENZYMATIC ASSEMBLY AND MITOCHONDRIA DRUG DELIVERY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-05-16 US claimed
CN-118021978-A GHRH antagonists for use in methods of treating sarcoidosis 迈阿密大学 2024-05-14 CN claimed
EP-4331674-A2 GHRH ANTAGONISTS FOR USE IN A METHOD OF TREATING SARCOIDOSIS University of Miami (US) 2024-03-06 EP claimed
US-20240051992-A1 THIOPHOSPHOPEPTIDES FOR ULTRAFAST TARGETING OF THE GOLGI APPARATUS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-02-15 US claimed
US-11839661-B2 Rapid formation of supramolecular hydrogels by short peptide and bioactive small molecules BRANDEIS UNIVERSITY (US) 2023-12-12 US claimed
US-11834517-B2 Branched peptides for enzymatic assembly and mitochondria drug delivery BRANDEIS UNIVERSITY (US) 2023-12-05 US claimed
EP-3999095-B1 GHRH ANTAGONISTS FOR USE IN A METHOD OF TREATING SARCOIDOSIS UNIV MIAMI (US) 2023-09-13 EP claimed
CN-116003323-A Fluorine-containing pyrazole phenylacetamide derivative and application thereof 西北农林科技大学 2023-04-25 CN claimed
WO-2022271798-A1 ENZYMATICALLY FORMING INTRANUCLEAR PEPTIDE ASSEMBLIES FOR SELECTIVELY KILLING INDUCED PLURIPOTENT STEM CELLS BRANDEIS UNIVERSITY (US) 2022-12-29 WO claimed
CN-115515617-A Diamine-linked receptor-specific cyclic peptides 帕拉丁科技公司 2022-12-23 CN claimed
EP-0315367-A2 Polypeptides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-05-10 EP claimed
US-4804650-A DIURETICS, VASODILATORS BIOTECHNOLOGY RESEARCH ASSOCIATES, J.V. (US) 1989-02-14 US claimed
EP-0237082-A2 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors SYNTEX (U.S.A.) INC. (US) 1987-09-16 EP claimed
EP-0223143-A2 Analogs of atrial natriuretic peptides CALIFORNIA BIOTECHNOLOGY, INC. (US) 1987-05-27 EP claimed
WO-1987002674-A1 ANALOGS OF ATRIAL NATRIURETIC PEPTIDES BIOTECHNOLOGY RESEARCH ASSOCIATES, J.V. (US) 1987-05-07 WO claimed
US-4269773-A CEPHALOSPORINS SHIONOGI & CO., LTD. (JP) 1981-05-26 US claimed
US-4267340-A BACTERICIDES; SYNTHESIS OF PENICILLINS AND CEPHALOSPORINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-05-12 US claimed
US-4092474-A Cephalosporins having a metaloxy group in 3-substituent SHIONOGI & CO., LTD. (JA) 1978-05-30 US claimed
US-4009159-A PENICILLINS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1977-02-22 US claimed
US-3993646-A Process for the ring expansion of penicillins to cephalosporin compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-11-23 US claimed