Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991731 | 0.79 | ADRA2C (0.48) | TSHRADRA2CCYP3A4ALOX15CHRM2 | |
| SCHEMBL9843925 | 0.73 | MTOR (0.48) | TSHRADRA2CCYP3A4ALOX15CHRM2 | |
| SCHEMBL3281034 | 0.72 | MTOR (0.57) | TSHRCYP3A4ALOX15CYP2D6HTR2A | |
| SCHEMBL4778223 | 0.72 | LMNA (0.48) | TSHRADRA2CCYP3A4ALOX15CHRM2 | |
| SCHEMBL21836227 | 0.72 | SIGMAR1 (0.55) | TSHRCYP3A4ALOX15CHRM2ADRA1A | |
| SCHEMBL21836226 | 0.72 | SIGMAR1 (0.55) | TSHRCYP3A4ALOX15CHRM2ADRA1A | |
| SCHEMBL1696698 | 0.71 | TDP1 (0.54) | TSHRADRA2CCYP3A4ALOX15CHRM2 | |
| SCHEMBL11100775 | 0.70 | MTOR (0.44) | TSHRADRA2CCYP3A4ALOX15CHRM2 | |
| SCHEMBL28984180 | 0.70 | LMNA (0.46) | TSHRADRA2CCYP3A4ALOX15KDM4E | |
| SCHEMBL8766752 | 0.69 | LMNA (0.49) | TSHRCYP2D6HSD17B10KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2736895-A1 | 2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER | Astrazeneca AB (SE) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013014448-A1 | 2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2013-01-31 | — | — | WO | disclosed |