Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CD74 | P04233 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15456828 | 0.85 | MYC (0.41) | ALDH1A1KDM4EMYCCD74MIF | |
| SCHEMBL3266678 | 0.81 | MEN1 (0.41) | ALDH1A1KDM4ECD74MIFMAPT | |
| SCHEMBL7035188 | 0.69 | SMN1; SMN2 (0.37) | ALDH1A1KDM4ECD74MIFMAPT | |
| SCHEMBL1629578 | 0.66 | NPC1 (0.39) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL308186 | 0.65 | MEN1 (0.48) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL30003181 | 0.65 | MEN1 (0.48) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3241412 | 0.63 | SMN1; SMN2 (0.38) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| Anthracene SCHEMBL28140459 | 0.63 | ALDH1A1 (0.58) | ALDH1A1GAAKDM4EIDO1MAPT | |
| SCHEMBL1004596 | 0.62 | KDM4E (0.63) | ALDH1A1GAAKDM4EIDO1MAPT | |
| SCHEMBL5968259 | 0.62 | MEN1 (0.44) | ALDH1A1GAAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071165-A1 | Aza- and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2011-03-24 | — | — | US | disclosed |
| US-20110071165-A1 | Aza- and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2011-03-24 | — | — | US | disclosed |
| US-20110071165-A1 | Aza- and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2011-03-24 | — | — | US | disclosed |
| US-20080293696-A1 | 2-Aminoarylcarboxamides Useful as Cancer Chemotherapeutic Agents | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1765811-A2 | 2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS | Bayer Pharmaceuticals Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060287339-A1 | Aza- and polyazanthranyl amides and their use as medicaments | SEIDELMANN DIETER | 2006-12-21 | — | — | US | disclosed |
| US-20060287339-A1 | Aza- and polyazanthranyl amides and their use as medicaments | SEIDELMANN DIETER | 2006-12-21 | — | — | US | disclosed |
| US-20060287339-A1 | Aza- and polyazanthranyl amides and their use as medicaments | SEIDELMANN DIETER | 2006-12-21 | — | — | US | disclosed |
| WO-2006002383-A2 | 2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20040224968-A1 | Aza-and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2004-11-11 | — | — | US | disclosed |
| US-20040224968-A1 | Aza-and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2004-11-11 | — | — | US | disclosed |
| US-20040224968-A1 | Aza-and polyazanthranyl amides and their use as medicaments | NOVARTIS AG (CH) | 2004-11-11 | — | — | US | disclosed |
| WO-2001085715-A3 | AZA- AND POLYAZANTHRANYL AMIDES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2002-04-18 | — | — | WO | disclosed |
| WO-2001085715-A2 | AZA- AND POLYAZANTHRANYL AMIDES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287339-A1 | Aza- and polyazanthranyl amides and their use as medicaments | VEGFA, AZI2, TPMT | ALDH1A1 764/4885GAA 371/4885KDM4E 745/4885 |
| US-20040224968-A1 | Aza-and polyazanthranyl amides and their use as medicaments | AZI2, VEGFA, TPMT | ALDH1A1 530/4885GAA 849/4885KDM4E 415/4885 |
| US-20080293696-A1 | 2-Aminoarylcarboxamides Useful as Cancer Chemotherapeutic Agents | ABCC3, HCCS, ABCC2 | ALDH1A1 611/4885GAA 4062/4885KDM4E 975/4885 |
| US-20110071165-A1 | Aza- and polyazanthranyl amides and their use as medicaments | VEGFA, AZI2, TPMT | ALDH1A1 764/4885GAA 371/4885KDM4E 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.