⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15220268 | 0.78 | ERN1 (0.38) | — | |
| SCHEMBL8645191 | 0.76 | — | — | |
| SCHEMBL6305183 | 0.76 | — | — | |
| SCHEMBL8028559 | 0.76 | — | — | |
| SCHEMBL13706019 | 0.76 | — | — | |
| SCHEMBL25316693 | 0.76 | — | — | |
| SCHEMBL4708819 | 0.72 | DAO (0.39) | — | |
| SCHEMBL9226039 | 0.72 | MEN1 (0.30) | — | |
| SCHEMBL5698253 | 0.72 | PTPN2 (0.31) | — | |
| SCHEMBL27968493 | 0.72 | ALDH1A1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363673-A1 | 5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases | PFIZER INC. (US) | 2022-11-17 | — | — | US | disclosed |
| EP-3990452-A1 | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES | Pfizer Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020261144-A1 | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020261144-A1 | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| US-20130225617-A1 | INDOLES AND THEIR THERAPEUTIC USE | PULMAGEN THERAPEUTICS (ASTHMA) LIMITED (GB) | 2013-08-29 | — | — | US | disclosed |
| US-8394836-B2 | Indoles and their therapeutic use | PULMAGEN THERAPEUTICS (ASTHMA) LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| EP-2327693-B9 | Indoles and their therapeutic use | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2012-10-24 | — | — | EP | disclosed |
| EP-2327693-B1 | Indoles and their therapeutic use | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2012-06-20 | — | — | EP | disclosed |
| EP-2327693-A1 | Indoles and their therapeutic use | Pulmagen Therapeutics (Asthma) Limited (GB) | 2011-06-01 | — | — | EP | disclosed |
| US-20110071175-A1 | Indoles and Their Therapeutic Use | GB005, INC. | 2011-03-24 | — | — | US | disclosed |
| EP-2229358-A1 | INDOLES AND THEIR THERAPEUTIC USE | Pulmagen Therapeutics (Asthma) Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077728-A1 | INDOLES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |
| US-4017313-A | Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-04-12 | — | — | US | disclosed |