Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.64 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.64 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 10/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.63 |
| ▸ | HPGD | P15428 | 7/20 | 0.63 |
| ▸ | POLB | P06746 | 6/20 | 0.63 |
| ▸ | GLA | P06280 | 4/20 | 0.63 |
| ▸ | BLM | P54132 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409923 | 0.97 | MEN1 (0.68) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL21409922 | 0.93 | MEN1 (0.53) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL3432144 | 0.88 | MAPT (0.73) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL417622 | 0.88 | MAPT (0.55) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL14669405 | 0.84 | TCF4 (0.53) | KDM4ESMN1; SMN2NPC1RAB9ACHEK2 | |
| SCHEMBL14669318 | 0.84 | CHEK1 (0.56) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL18806843 | 0.84 | MEN1 (0.52) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL2686936 | 0.83 | NPC1 (0.54) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL15443982 | 0.83 | MEN1 (0.87) | MEN1KMT2ARXFP1CACNA1BAPBA1 | |
| SCHEMBL14859469 | 0.82 | NPC1 (0.52) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056887-B2 | Minor groove binder phosphoramidites and methods of use | ELITECH HOLDING B.V. (NL) | 2015-06-16 | — | — | US | disclosed |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | ELITECH HOLDING B.V. | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | PCNA, CD2BP2, BPGM | MEN1 3125/4885KMT2A 2501/4885RXFP1 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.