SCHEMBL146701

SCHEMBL146701

CCCCNc1nc2c(N(Cc3ccccc3)Cc3ccccc3)nc3ccccc3c2n1CC(C)C

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 15/20 0.44
CASP6 P55212 1/20 0.42
POLB P06746 2/20 0.39
MAPT P10636 2/20 0.39
TLR8 Q9NR97 3/20 0.37
TP53 P04637 1/20 0.37
ACP1 P24666 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12245200 0.94 APP (0.42) TLR7POLBTLR8
SCHEMBL1046834 0.88 L3MBTL1 (0.39) TLR7TLR8
SCHEMBL142891 0.86 TLR7 (0.38) TLR7POLBTLR8
SCHEMBL31092876 0.86 TLR7 (0.38) TLR7POLBTLR8
SCHEMBL4207212 0.82 MEN1 (0.46) TLR7POLBMAPTTP53ACP1
SCHEMBL4620764 0.82 TLR7 (0.34) TLR7POLBTLR8
SCHEMBL149093 0.82 TLR7 (0.52) TLR7POLBTLR8
SCHEMBL29988385 0.81 TLR7 (0.39) TLR7
SCHEMBL146804 0.81 TLR7 (0.39) TLR7
SCHEMBL12245248 0.81 KMT2A (0.44) TLR7MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130096103-A1 IMIDAZOQUINOLINE COMPOUNDS NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) 2013-04-18 US claimed
US-20110217323-A1 IMIDAZOQUINOLINE COMPOUNDS NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) 2011-09-08 US claimed
US-20080213308-A1 Imidazoquinoline Compounds NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2008-09-04 US claimed
EP-4585610-A2 MAKING INFLUENZA VIRUS VACCINES WITHOUT USING EGGS Seqirus UK Limited (GB) 2025-07-16 EP disclosed
EP-4144368-B1 RSV IMMUNIZATION REGIMEN GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2025-02-26 EP disclosed
EP-3527224-B1 RSV IMMUNIZATION REGIMEN GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2025-02-26 EP disclosed
US-20250042951-A1 PRE-FUSION RSV F ANTIGENS NOVARTIS AG (CH) 2025-02-06 US disclosed
US-12139512-B2 Pre-fusion RSV F antigens GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2024-11-12 US disclosed
US-20240299537-A1 ADJUVANTED VACCINES WITH NON-VIRION ANTIGENS PREPARED FROM INFLUENZA VIRUSES GROWN IN CELL CULTURE SEQIRUS UK LTD (GB) 2024-09-12 US disclosed
US-20240299527-A1 RSV IMMUNIZATION REGIMEN NOVARTIS AG (CH) 2024-09-12 US disclosed
EP-4183412-B1 RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2024-08-14 EP disclosed
WO-2007105115-A2 COMPOSITIONS AND METHODS FOR IMMUNISATION USING CD1D LIGANDS NOVARTIS VACCINES AND DIAGNOSTICS SRL (IT) 2007-09-20 WO disclosed
WO-2007100699-A2 MICROPARTICLES CONTAINING BIODEGRADABLE POLYMER AND CATIONIC POLYSACCHARIDE FOR USE IN IMMUNOGENIC COMPOSITIONS NOVARTIS AG (CH) 2007-09-07 WO disclosed
EP-1797091-A2 IMIDAZOQUINOLINE COMPOUNDS Novartis Vaccines and Diagnostics, Inc. (US) 2007-06-20 EP disclosed
WO-2007052058-A1 INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS NOVARTIS VACCINES AND DIAGNOSTICS SRL (IT) 2007-05-10 WO disclosed
WO-2007041432-A2 CROSS-NEUTRALIZATION OF HCV WITH RECOMBINANT PROTEINS NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2007-04-12 WO disclosed
WO-2006091517-A2 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) 2006-08-31 WO disclosed
WO-2006089264-A2 PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) 2006-08-24 WO disclosed
WO-2006067632-A2 SACCHARIDE CONJUGATE VACCINES NOVARTIS VACCINES AND DIAGNOSTICS SRL (IT) 2006-06-29 WO disclosed
WO-2006031878-A2 IMIDAZOQUINOLINE COMPOUNDS NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) 2006-03-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250042951-A1 PRE-FUSION RSV F ANTIGENS FURIN, CD69, LY96 TLR7 485/4885CASP6 3690/4885POLB 3894/4885
US-12139512-B2 Pre-fusion RSV F antigens FURIN, CD69, LY96 TLR7 485/4885CASP6 3690/4885POLB 3894/4885
US-20130096103-A1 IMIDAZOQUINOLINE COMPOUNDS IFNG, IRF3, MYD88 TLR7 13/4885CASP6 3447/4885POLB 2702/4885
US-20240299527-A1 RSV IMMUNIZATION REGIMEN IL5, IL15, IFNG TLR7 48/4885CASP6 2364/4885POLB 1481/4885
US-20110217323-A1 IMIDAZOQUINOLINE COMPOUNDS IFNG, IRF3, MYD88 TLR7 13/4885CASP6 3447/4885POLB 2702/4885
US-20240299537-A1 ADJUVANTED VACCINES WITH NON-VIRION ANTIGENS PREPARED FROM INFLUENZA VIRUSES GROWN IN CELL CULTURE LY96, PHOSPHO1, ASGR1 TLR7 73/4885CASP6 3789/4885POLB 1062/4885
US-20080213308-A1 Imidazoquinoline Compounds IFNG, IRF3, MYD88 TLR7 13/4885CASP6 3447/4885POLB 2702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.