Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 9/20 | 0.55 |
| ▸ | PAK4 | O96013 | 5/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | PLK4 | O00444 | 4/20 | 0.55 |
| ▸ | IGF1R | P08069 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218642 | 0.85 | MEN1 (0.62) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL12105461 | 0.75 | AURKA (0.52) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL14670652 | 0.74 | MEN1 (0.52) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL218565 | 0.74 | PAK4 (0.60) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL18853845 | 0.73 | JAK2 (0.84) | AURKAPAK4AURKBJAK2FGFR1 | |
| Azd-1480 SCHEMBL219103 | 0.71 | JAK2 (1.00) | AURKAPAK4AURKBJAK2FGFR1 | |
| SCHEMBL2121130 | 0.71 | IGF1R (1.00) | AURKAPAK4AURKBJAK2FGFR1 | |
| SCHEMBL4038322 | 0.71 | FGFR1 (0.59) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL4034569 | 0.71 | IGF1R (0.66) | AURKAPAK4AURKBJAK2FGFR1 | |
| Azd-1480 SCHEMBL3345019 | 0.71 | JAK2 (1.00) | AURKAPAK4AURKBJAK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |