Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1468586 | 0.90 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL10085882 | 0.87 | NPC1 (0.67) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL10085846 | 0.82 | NPC1 (0.56) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL1468608 | 0.82 | NPC1 (0.50) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL10086409 | 0.82 | CYP11B2 (0.56) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL10086211 | 0.82 | NPC1 (0.53) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL4255757 | 0.81 | PARP1 (0.49) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL10086523 | 0.81 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL4253069 | 0.81 | CYP11B2 (0.55) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL4250783 | 0.80 | NPC1 (0.56) | NPC1RAB9ATP53SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722723-B2 | Aromatic amide derivative | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| US-20120083495-A1 | COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, | 2012-04-05 | — | — | US | disclosed |
| US-8110681-B2 | Compounds for the treatment of spinal muscular atrophy and other uses | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110681-B2 | Compounds for the treatment of spinal muscular atrophy and other uses | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-02-07 | — | — | US | disclosed |
| US-20110071304-A1 | AROMATIC AMIDE DERIVATIVE | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071304-A1 | AROMATIC AMIDE DERIVATIVE | NCOR2, NCOR1, EP300 | NPC1 2827/4885RAB9A 1837/4885TP53 1540/4885 |
| US-20120083495-A1 | COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | SMN1; SMN2, RNMT, CPT1B | NPC1 1076/4885RAB9A 1487/4885TP53 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.