Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CBLB | Q13191 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SDCBP | O00560 | 1/20 | 0.38 |
| ▸ | SDC2 | P34741 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250602 | 0.89 | HTR2C (0.47) | CYP11B2CYP11B1HTR2CPARP1CBLB | |
| SCHEMBL4255757 | 0.86 | PARP1 (0.49) | CYP11B2CYP11B1PARP1NPC1RAB9A | |
| SCHEMBL4250783 | 0.84 | NPC1 (0.56) | CYP11B2CYP11B1HTR2CPARP1NPC1 | |
| SCHEMBL4251115 | 0.83 | PARP1 (0.46) | CYP11B2CYP11B1PARP1NPC1RAB9A | |
| SCHEMBL4258064 | 0.83 | PARP1 (0.46) | CYP11B2CYP11B1PARP1NPC1RAB9A | |
| SCHEMBL10086409 | 0.82 | CYP11B2 (0.56) | CYP11B2CYP11B1HTR2CCBLBNPC1 | |
| SCHEMBL1467522 | 0.81 | NPC1 (0.47) | CYP11B2CYP11B1PARP1CBLBNPC1 | |
| SCHEMBL4254589 | 0.81 | NPC1 (0.59) | HTR2CPARP1NPC1RAB9APKM | |
| SCHEMBL4258304 | 0.80 | NPC1 (0.69) | CYP11B2HTR2CPARP1NPC1RAB9A | |
| SCHEMBL4253666 | 0.79 | HTR2C (0.58) | CYP11B2CYP11B1HTR2CCBLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | claimed |
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | disclosed |