Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GLS | O94925 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679372 | 0.95 | MAPT (0.56) | POLBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL14679129 | 0.95 | MAPT (0.53) | POLBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8399573 | 0.86 | GPR119 (0.53) | GLSIDO1MAPK8NQO2ANO1 | |
| SCHEMBL16787407 | 0.85 | POLB (0.62) | POLBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL22452352 | 0.84 | POLB (0.53) | POLBALDH1A1MAPTATMGLS | |
| SCHEMBL27099066 | 0.84 | ALDH1A1 (0.48) | POLBALDH1A1NPC1GLSMAPK8 | |
| SCHEMBL14679418 | 0.83 | HPGD (0.57) | POLBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1295524 | 0.83 | POLB (0.49) | POLBALDH1A1KMT2ANPC1MAPT | |
| SCHEMBL16155837 | 0.83 | MAPT (0.59) | POLBMEN1KMT2ANPC1MAPT | |
| SCHEMBL8279661 | 0.82 | POLB (0.53) | POLBALDH1A1MAPTATMGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |