Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679129 | 0.97 | MAPT (0.53) | MAPTATMPOLBCYP3A4GLS | |
| SCHEMBL14679447 | 0.95 | POLB (0.53) | MAPTATMPOLBCYP3A4GLS | |
| SCHEMBL16155837 | 0.86 | MAPT (0.59) | MAPTATMPOLBCYP3A4MEN1 | |
| SCHEMBL14679377 | 0.84 | HPGD (0.62) | MAPTCYP3A4MEN1ALDH1A1KMT2A | |
| SCHEMBL16787407 | 0.83 | POLB (0.62) | MAPTATMPOLBMEN1ALDH1A1 | |
| SCHEMBL27099066 | 0.82 | ALDH1A1 (0.48) | POLBGLSALDH1A1NPC1TDP1 | |
| SCHEMBL9797776 | 0.81 | DRD2 (0.52) | CYP3A4MEN1KMT2ATDP1CA1 | |
| SCHEMBL14679451 | 0.81 | NPC1 (0.54) | ATMGLSMEN1ALDH1A1KMT2A | |
| SCHEMBL8399573 | 0.81 | GPR119 (0.53) | GLS | |
| SCHEMBL1295524 | 0.81 | POLB (0.49) | MAPTATMPOLBGLSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |