Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MAOA | P21397 | 6/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PLEC | Q15149 | 1/20 | 0.51 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 3/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047900 | 0.79 | MEN1 (0.59) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL29385801 | 0.78 | MEN1 (1.00) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL160038 | 0.78 | MEN1 (1.00) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL30721500 | 0.76 | MEN1 (0.95) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL11413119 | 0.76 | MEN1 (0.95) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL25194269 | 0.76 | MEN1 (0.95) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL29277729 | 0.76 | MEN1 (0.95) | MAPTMEN1KMT2AMAOATDP1 | |
| Quinizarin SCHEMBL27809404 | 0.76 | MEN1 (0.95) | MAPTMEN1KMT2AMAOATDP1 | |
| SCHEMBL30341064 | 0.75 | MAPT (0.68) | MAPTMEN1KMT2AMAOATDP1 | |
| SCHEMBL8427136 | 0.75 | MAPT (0.68) | MAPTMEN1KMT2AMAOATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | SPINT2, ADAM17, ADAM33 | MAPT 383/4885MEN1 4291/4885KMT2A 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.