Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.68 |
| ▸ | PTPRC | P08575 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2347136 | 0.89 | S100A4 (0.84) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL14922766 | 0.89 | S100A4 (0.62) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL11317413 | 0.85 | S100A4 (0.78) | S100A4PTPRCTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL11752865 | 0.84 | TSHR (0.75) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| Anthraquinone SCHEMBL27736010 | 0.84 | S100A4 (0.79) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL156735 | 0.84 | S100A4 (0.79) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL11210972 | 0.84 | S100A4 (0.75) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL1303600 | 0.83 | S100A4 (0.81) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL6051840 | 0.83 | TSHR (0.69) | S100A4PTPRCLMNATSHRSMN1; SMN2 | |
| SCHEMBL8777750 | 0.83 | S100A4 (0.68) | S100A4PTPRCSMN1; SMN2HSD17B10CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778876-B2 | Small-molecule inhibitors of Dengue and West Nile virus proteases | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035284-A1 | SMALL-MOLECULE INHIBITORS OF DENGUE AND WEST NILE VIRUS PROTEASES | SPINT2, ADAM17, ADAM33 | S100A4 3199/4885PTPRC 573/4885LMNA 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.