Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | DRD1 | P21728 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20785603 | 0.77 | DRD2 (0.54) | DRD2PIM1HTR1ADRD1HTR2A | |
| SCHEMBL27056167 | 0.74 | ADRA2A (0.43) | DRD2PIM1HTR1ADRD1HTR2A | |
| SCHEMBL15362395 | 0.74 | PIM1 (0.48) | DRD2PIM1HTR1ADRD1HTR2A | |
| SCHEMBL20786073 | 0.72 | DRD2 (0.63) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL29384252 | 0.71 | PIM1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL380206 | 0.71 | PIM1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL2577719 | 0.71 | PIM1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL12434241 | 0.71 | PIM1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL9566 | 0.71 | PIM1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A | |
| Thioridazine SCHEMBL41430 | 0.71 | TDP1 (1.00) | DRD2PIM1HTR1ADRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013017637-A1 | SELECTIVE INHIBITION OF MALT1 PROTEASE BY PHENOTHIAZINE DERIVATIVES | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2013-02-07 | — | — | WO | disclosed |