Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27056141 | 0.76 | KDM1A (0.39) | ADRA2AHTR1ADRD1DRD3CHRM2 | |
| SCHEMBL14434182 | 0.76 | CHRM2 (0.54) | ADRA2AHTR1ADRD1DRD3CYP1A2 | |
| SCHEMBL14433981 | 0.76 | CHRM2 (0.54) | ADRA2AHTR1ADRD1DRD3CYP1A2 | |
| SCHEMBL14434185 | 0.76 | CHRM2 (0.54) | ADRA2AHTR1ADRD1DRD3CYP1A2 | |
| SCHEMBL27056189 | 0.75 | CYP2D6 (0.40) | ADRA2AHTR6HTR1ADRD1DRD3 | |
| SCHEMBL19759877 | 0.75 | ALDH1A1 (0.33) | MAOAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL27056147 | 0.74 | KCNH2 (0.41) | ADRA2AHTR6DRD1DRD3CYP1A2 | |
| SCHEMBL14682732 | 0.74 | DRD2 (0.56) | ADRA2APIM1HTR6HTR1ADRD1 | |
| SCHEMBL15362395 | 0.73 | PIM1 (0.48) | ADRA2APIM1HTR6HTR1ADRD1 | |
| SCHEMBL29799376 | 0.71 | PIM1 (0.63) | ADRA2APIM1HTR6HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3473254-B1 | PHENOTHIAZINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE DISEASES | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH (DE) | 2024-01-24 | — | — | EP | disclosed |