Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403954 | 0.89 | HDAC1 (0.35) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL14318353 | 0.81 | MEN1 (0.42) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL14684729 | 0.79 | SMN1; SMN2 (0.50) | KMT2ARAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL14315448 | 0.78 | NR1H4 (0.43) | RAB9AALDH1A1NPC1SMN1; SMN2HTT | |
| SCHEMBL14224988 | 0.77 | RAB9A (0.41) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL16404150 | 0.77 | RAB9A (0.42) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL16403938 | 0.77 | HPGD (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MAPT | |
| SCHEMBL14224958 | 0.75 | ALDH1A1 (0.43) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL16403920 | 0.75 | ALDH1A1 (0.38) | KMT2AMEN1RAB9AALDH1A1NPC1 | |
| SCHEMBL16404071 | 0.75 | RAB9A (0.40) | KMT2AMEN1RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |