Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 18/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685955 | 0.86 | KDM4E (0.41) | KDM4EPDE5AHDAC1HDAC6HDAC2 | |
| SCHEMBL14686005 | 0.86 | PDE5A (0.39) | KDM4EPDE5AHDAC1HDAC6HDAC2 | |
| SCHEMBL14686015 | 0.80 | KDM4E (0.45) | KDM4EPDE5AHDAC1HDAC6HDAC2 | |
| SCHEMBL3671939 | 0.76 | PDE5A (0.55) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL17333641 | 0.74 | PDE5A (0.47) | KDM4EPDE5AHDAC1HDAC6HDAC2 | |
| SCHEMBL5988676 | 0.74 | PDE5A (0.48) | PDE5AHDAC1HDAC6HDAC2PDE2A | |
| SCHEMBL16972452 | 0.74 | PDE1A (0.48) | KDM4EPDE5APDE2APDE9APDE4A | |
| SCHEMBL5085823 | 0.73 | PDE5A (0.56) | PDE5AHDAC1HDAC6HDAC2HDAC3 | |
| SCHEMBL7002705 | 0.72 | KDM4E (0.73) | KDM4EPDE5AHDAC1HDAC6HDAC2 | |
| SCHEMBL7007807 | 0.72 | KDM4E (0.61) | KDM4EPDE5AHDAC1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | disclosed |