Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.56 |
| ▸ | PDE6C | P51160 | 2/20 | 0.56 |
| ▸ | PDE9A | O76083 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990273 | 0.95 | PDE5A (0.50) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL17333641 | 0.93 | PDE5A (0.47) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL7019558 | 0.82 | PARP1 (0.41) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL6058528 | 0.81 | PDE5A (0.67) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL5085819 | 0.79 | PDE5A (0.65) | PDE5APDE6CMAPTALDH1A1MEN1 | |
| SCHEMBL16972452 | 0.75 | PDE1A (0.48) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL3671939 | 0.74 | PDE5A (0.55) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL1872915 | 0.74 | PDE5A (0.58) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL7085453 | 0.74 | PDE5A (0.36) | PDE5APDE6CPDE9APDE1APDE1B | |
| SCHEMBL14685955 | 0.73 | KDM4E (0.41) | PDE5APDE6CPDE9APDE1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702555-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1996-03-27 | — | — | EP | claimed |
| WO-1994028902-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1994-12-22 | — | — | WO | claimed |
| EP-1965863-A2 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF LUTS COMPRISING A PDE5 INHIBITOR AND A MUSCARINIC ANTAGONIST | Pfizer Products Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072169-A2 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF LUTS COMPRISING A PDE5 INHIBITOR AND A MUSCARINIC ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |