Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.47 |
| ▸ | PDE6C | P51160 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085823 | 0.93 | PDE5A (0.56) | PDE5APDE6CMAPTHDAC1HDAC6 | |
| SCHEMBL5990273 | 0.88 | PDE5A (0.50) | PDE5APDE6CMAPTALDH1A1MEN1 | |
| SCHEMBL7019558 | 0.84 | PARP1 (0.41) | PDE5APDE6CMAPTHDAC1HDAC6 | |
| SCHEMBL16972452 | 0.77 | PDE1A (0.48) | PDE5APDE6CMAPTALDH1A1ALOX15 | |
| SCHEMBL3671939 | 0.76 | PDE5A (0.55) | PDE5APDE6CPDE3BPDE3APDE2A | |
| SCHEMBL7085453 | 0.76 | PDE5A (0.36) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL14685955 | 0.75 | KDM4E (0.41) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL5988676 | 0.74 | PDE5A (0.48) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL14686017 | 0.74 | KDM4E (0.39) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL6058528 | 0.73 | PDE5A (0.67) | PDE5APDE6CMAPTALDH1A1PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150359798-A1 | PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY | JANSFAT BIOTECHNOLOGY CO., LTD. (TW) | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150359798-A1 | PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY | FABP1, LIPC, PLIN5 | PDE5A 570/4885PDE6C 3718/4885MAPT 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.