Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16114579 | 0.79 | TRPV4 (0.53) | TRPV4NR3C1PGRLPAR1DRD1 | |
| SCHEMBL14686369 | 0.76 | TRPV4 (0.43) | TRPV4NR3C1PGRNFE2L2DRD1 | |
| SCHEMBL14686367 | 0.74 | L3MBTL1 (0.46) | SLC22A12DRD1 | |
| SCHEMBL2376210 | 0.73 | TRPV4 (0.54) | TRPV4NR3C1PGRLPAR1TYK2 | |
| SCHEMBL31328368 | 0.71 | TRPV4 (0.51) | TRPV4NR3C1PGRLPAR1TYK2 | |
| SCHEMBL22679340 | 0.70 | TRPV4 (0.50) | TRPV4NR3C1PGRLPAR1TYK2 | |
| SCHEMBL21144313 | 0.70 | TRPV4 (1.00) | TRPV4NR3C1PGRNFE2L2SLC22A12 | |
| SCHEMBL14686293 | 0.70 | PTGS1 (0.34) | TRPV4NFE2L2 | |
| SCHEMBL14686399 | 0.70 | CA12 (0.36) | TRPV4NFE2L2 | |
| SCHEMBL2646025 | 0.70 | TRPV4 (0.57) | TRPV4NR3C1PGRLPAR1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865940-B1 | ALPHA KETOAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | VIROBAY INC (US) | 2013-02-13 | — | — | EP | claimed |