Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenretinide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA known ✓ | P19793 | 5/20 | 0.72 |
| ▸ | RARA known ✓ | P10276 | 4/20 | 0.72 |
| ▸ | RARB known ✓ | P10826 | 4/20 | 0.72 |
| ▸ | RARG known ✓ | P13631 | 4/20 | 0.72 |
| ▸ | RXRB known ✓ | P28702 | 2/20 | 0.72 |
| ▸ | RXRG known ✓ | P48443 | 2/20 | 0.72 |
| ▸ | RBP4 | P02753 | 7/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.94 |
| ▸ | MAPT | P10636 | 6/20 | 0.94 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.94 |
| ▸ | BLM | P54132 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 3/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.94 |
| ▸ | MEN1 | O00255 | 2/20 | 0.94 |
| ▸ | GMNN | O75496 | 2/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.94 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenretinide SCHEMBL15703189 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL4874840 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL11703 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL10629371 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL13402304 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL9838209 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL839699 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL19121 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL11704 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 | |
| Fenretinide SCHEMBL4996036 | 0.97 | RBP4 (1.00) | RBP4ALDH1A1MAPTHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3263583-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | Pharmascience Inc. (CA) | 2018-01-03 | — | — | EP | disclosed |
| EP-2534170-B1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC (CA) | 2017-04-19 | — | — | EP | disclosed |
| US-9284350-B2 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2016-03-15 | — | — | US | disclosed |
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC. (CA) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | RXRA 4378/4885RARA 3987/4885RARB 3123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.