SCHEMBL14690729

SCHEMBL14690729

Nc1ccc2ccccc2c1N=Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SENP7 Q9BQF6 3/20 0.50
▸ SENP2 Q9HC62 2/20 0.50
▸ SENP1 Q9P0U3 2/20 0.50
▸ CCNE2 O96020 1/20 0.50
▸ CCNE1 P24864 1/20 0.50
▸ CDK2 P24941 1/20 0.50
▸ SUMO2 P61956 1/20 0.50
▸ SUMO1 P63165 1/20 0.50
▸ SENP3 Q9H4L4 1/20 0.50
▸ MAPT P10636 7/20 0.49
▸ MEN1 O00255 7/20 0.49
▸ KMT2A Q03164 7/20 0.49
▸ MAPK1 P28482 4/20 0.48
▸ RAB9A P51151 4/20 0.48
▸ CASP3 P42574 2/20 0.48
▸ SENP8 Q96LD8 2/20 0.48
▸ SENP6 Q9GZR1 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ NQO2 P16083 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14690728 1.00 SENP7 (0.50) SENP7SENP2SENP1CCNE2CCNE1
SCHEMBL29357277 0.84 MAPT (0.67) SENP7MAPTMEN1KMT2AMAPK1
SCHEMBL18769 0.84 MAPT (0.67) SENP7MAPTMEN1KMT2AMAPK1
SCHEMBL2436925 0.84 MAPT (0.67) SENP7MAPTMEN1KMT2AMAPK1
SCHEMBL29372851 0.84 MAPT (0.67) SENP7MAPTMEN1KMT2AMAPK1
SCHEMBL28542320 0.83 MAPT (0.65) SENP7MAPTMEN1KMT2AMAPK1
SCHEMBL10999478 0.83 THRB (0.62) SENP7SENP2SENP1CCNE2CCNE1
SCHEMBL10999474 0.83 THRB (0.62) SENP7SENP2SENP1CCNE2CCNE1
SCHEMBL4698006 0.82 NQO2 (0.48) SENP7CCNE2CCNE1CDK2MAPT
SCHEMBL295205 0.81 THRB (0.64) SENP7SENP2SENP1CCNE2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2846848-B1 OPHTHALMIC VISCOELASTIC DEVICE ZEISS CARL MEDITEC AG (DE) 2018-03-07 — — EP disclosed
US-20150119356-A1 Ophthalmic Viscoelastic Device CARL ZEISS MEDITEC AG (DE) 2015-04-30 — — US disclosed
EP-2846848-A1 OPHTHALMIC VISCOELASTIC DEVICE Carl Zeiss Meditec AG (DE) 2015-03-18 — — EP disclosed
WO-2013167632-A1 OPHTHALMIC VISCOELASTIC DEVICE CARL ZEISS MEDITEC AG (DE) 2013-11-14 — — WO disclosed
WO-2013020917-A1 Ophthalmologic composition comprising an aqueous solution of at least one viscoelastic polysaccharide CARL ZEISS MEDITEC AG (DE) 2013-02-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150119356-A1 Ophthalmic Viscoelastic Device UACA, ICAM1, VIM SENP7 409/4885SENP2 1344/4885SENP1 637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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