SCHEMBL146908

SCHEMBL146908

Nc1nonc1C(=NO)Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IKBKE Q14164 1/20 0.52
ALDH1A1 P00352 3/20 0.49
MAPT P10636 5/20 0.47
TP53 P04637 2/20 0.47
KDR P35968 3/20 0.47
IDO1 P14902 4/20 0.46
FLT3 P36888 2/20 0.45
KIT P10721 1/20 0.45
IKBKB O14920 1/20 0.45
KMT2A Q03164 2/20 0.44
GAA P10253 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
LMNA P02545 1/20 0.44
PTGS1 P23219 1/20 0.43
AURKA O14965 1/20 0.43
DCLK1 O15075 1/20 0.43
DYRK3 O43781 1/20 0.43
ROCK2 O75116 1/20 0.43
MAP4K4 O95819 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL146907 1.00 IKBKE (0.52) IKBKEALDH1A1MAPTTP53KDR
SCHEMBL14443052 0.85 ALDH1A1 (0.49) ALDH1A1MAPTTP53KDRIDO1
SCHEMBL14964186 0.85 ALDH1A1 (0.49) ALDH1A1MAPTTP53KDRIDO1
SCHEMBL2516715 0.84 IDO1 (0.58) MAPTKDRIDO1KITLMNA
SCHEMBL2516712 0.84 IDO1 (0.58) MAPTKDRIDO1KITLMNA
SCHEMBL12054202 0.82 IKBKE (0.54) IKBKEALDH1A1MAPTTP53KDR
SCHEMBL6046661 0.82 NPC1 (0.46) MAPTIDO1KMT2ALMNAHTT
SCHEMBL6046663 0.82 NPC1 (0.46) MAPTIDO1KMT2ALMNAHTT
SCHEMBL4728320 0.81 MAPT (0.54) ALDH1A1MAPTKDRIDO1FLT3
SCHEMBL4728326 0.81 MAPT (0.54) ALDH1A1MAPTKDRIDO1FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3085697-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME Incyte Holdings Corporation (US) 2016-10-26 EP claimed
US-20140377292-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION (US) 2014-12-25 US claimed
US-20130123246-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION (US) 2013-05-16 US claimed
US-20110311479-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION, A DELAWARE CORPORATION 2011-12-22 US claimed
US-20060258719-A1 Modulators of indoleamine 2,3-dioxygenase and methods of using the same INCYTE CORPORATION 2006-11-16 US claimed
US-20240173303-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase INCYTE HOLDINGS CORPORATION 2024-05-30 US disclosed
EP-2911669-B1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER UNIV CHICAGO (US) 2024-04-10 EP disclosed
US-20220331296-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase INCYTE CORPORATION 2022-10-20 US disclosed
US-11207302-B2 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2021-12-28 US disclosed
US-20210228715-A1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER THE UNIVERSITY OF CHICAGO (US) 2021-07-29 US disclosed
US-10967060-B2 Synergistic combination of immunologic inhibitors for the treatment of cancer THE UNIVERSITY OF CHICAGO (US) 2021-04-06 US disclosed
US-20210030722-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase INCYTE CORPORATION 2021-02-04 US disclosed
US-20110311479-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION, A DELAWARE CORPORATION 2011-12-22 US disclosed
US-20110311479-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME INCYTE CORPORATION, A DELAWARE CORPORATION 2011-12-22 US disclosed
US-8034953-B2 Modulators of indoleamine 2,3-dioxygenase and methods of using the same INCYTE CORPORATION (US) 2011-10-11 US disclosed
US-8034953-B2 Modulators of indoleamine 2,3-dioxygenase and methods of using the same INCYTE CORPORATION (US) 2011-10-11 US disclosed
EP-2315756-A2 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE Incyte Corporation (US) 2011-05-04 EP disclosed
US-20100015178-A1 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE INCYTE CORPORATION 2010-01-21 US disclosed
WO-2010005958-A2 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE INCYTE CORPORATION (US) 2010-01-14 WO disclosed
US-20060258719-A1 Modulators of indoleamine 2,3-dioxygenase and methods of using the same INCYTE CORPORATION 2006-11-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210030722-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase IDO1, IDO2, INMT IKBKE 787/4885ALDH1A1 157/4885MAPT 3215/4885
US-20240173303-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase IDO1, IDO2, INMT IKBKE 787/4885ALDH1A1 157/4885MAPT 3215/4885
US-11207302-B2 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase IDO1, IDO2, INMT IKBKE 787/4885ALDH1A1 157/4885MAPT 3215/4885
US-20100015178-A1 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE IDO1, IDO2, INMT IKBKE 787/4885ALDH1A1 157/4885MAPT 3215/4885
US-20060258719-A1 Modulators of indoleamine 2,3-dioxygenase and methods of using the same IDO1, IDO2, INMT IKBKE 669/4885ALDH1A1 902/4885MAPT 3106/4885
US-20110311479-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME IDO1, IDO2, INMT IKBKE 669/4885ALDH1A1 902/4885MAPT 3106/4885
US-20210228715-A1 SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER ICOS, CD274, IDO1 IKBKE 118/4885ALDH1A1 393/4885MAPT 4080/4885
US-20220331296-A1 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase IDO1, IDO2, INMT IKBKE 787/4885ALDH1A1 157/4885MAPT 3215/4885
US-10967060-B2 Synergistic combination of immunologic inhibitors for the treatment of cancer ICOS, IDO1, IL2 IKBKE 98/4885ALDH1A1 351/4885MAPT 4589/4885
US-20140377292-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME IDO1, IDO2, INMT IKBKE 669/4885ALDH1A1 902/4885MAPT 3106/4885
US-20130123246-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME IDO1, IDO2, INMT IKBKE 669/4885ALDH1A1 902/4885MAPT 3106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.