SCHEMBL146936

SCHEMBL146936

[c]1ccc(N2CCCCC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.52
MAPT P10636 5/20 0.52
L3MBTL1 Q9Y468 4/20 0.52
ALOX15 P16050 3/20 0.52
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
KDM4E B2RXH2 2/20 0.52
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
GAA P10253 2/20 0.52
HTT P42858 2/20 0.52
USP2 O75604 1/20 0.52
TP53 P04637 1/20 0.52
POLB P06746 1/20 0.52
THRB P10828 1/20 0.52
RECQL P46063 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
HSD17B10 Q99714 1/20 0.52
CHKA P35790 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL693166 1.00 ALDH1A1 (0.52) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL1900341 1.00 ALDH1A1 (0.52) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL41297 0.97 CHKA (0.52) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL114702 0.92 CHKA (0.46) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL5795262 0.87
SCHEMBL11747202 0.87 ALDH1A1 (0.50) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL12478326 0.84 ALDH1A1 (0.47) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL5322825 0.82 L3MBTL1 (0.53) ALDH1A1MAPTL3MBTL1ALOX15MEN1
SCHEMBL4041212 0.82 L3MBTL3 (0.75) L3MBTL1L3MBTL3CYP2C19
SCHEMBL6887590 0.81 ALDH1A1 (0.71) ALDH1A1MAPTL3MBTL1ALOX15MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1685 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4399198-A2 DUAL INHIBITOR OF HISTONE DEACETYLASE 6 AND HEAT SHOCK PROTEIN 90 Taipei Medical University (TW) 2024-07-17 EP claimed
CN-118302401-A Dual inhibitors of histone deacetylase 6 and heat shock protein 90 台北医学大学 2024-07-05 CN claimed
WO-2024103023-A2 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS VERALOX THERAPEUTICS (US) 2024-05-16 WO claimed
WO-2024097846-A1 ORAL PHARMACEUTICAL FORMULATIONS CONTAINING 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES VERALOX THERAPEUTICS (US) 2024-05-10 WO claimed
EP-3778576-B1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME HANLIM PHARMACEUTICAL CO LTD (KR) 2024-04-17 EP claimed
WO-2024019959-A1 COMPOSITIONS FOR MODULATING LIPOXYGENASE AND METHODS OF USING SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-01-25 WO claimed
EP-3054936-B1 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS EASTERN VIRGINIA MEDICAL SCHOOL (US) 2023-10-18 EP claimed
CN-116554104-A Indenone and indazolone derivatives with antioxidant activity, and synthetic method and application thereof 西南大学 2023-08-08 CN claimed
US-20230167101-A1 NOVEL INHIBITORS OF HISTONE ACETYLTRANSFERASE P300/CBP FOR CANCER THERAPY BAYLOR COLLEGE OF MEDICINE (US) 2023-06-01 US claimed
CN-116143602-A Indenone and indazolone derivatives with antioxidant activity, and synthetic method and application thereof 西南大学 2023-05-23 CN claimed
EP-0411775-A1 Heterocyclic compounds containing nitrogen and sulfur, processes for their preparation and pharmaceutical compositions thereof RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) 1991-02-06 EP claimed
US-4960746-A A-HYDROXY-OR A-AMINO-ACETOPHENONES AND A TITANOCENE COMPOUND SUBSTITUTED BY FLUORINE CIBA-GEIGY CORPORATION (US) 1990-10-02 US claimed
EP-0269573-A2 Liquid photoinitiating mixture CIBA-GEIGY AG (CH) 1988-06-01 EP claimed
US-4716168-A STIMULANTS OF IMMUNE RESPONSE NORWICH EATON PHARMACEUTICALS, INC. (US) 1987-12-29 US claimed
EP-0231622-A2 Inhibition of the 5-lipoxygenase pathway SMITHKLINE BEECHAM CORPORATION (US) 1987-08-12 EP claimed
CN-86108538-A The inhibition of 5-lipoxygenase pathway 1987-07-29 CN claimed
EP-0187705-A2 Imidazo(4,5-f)quinolines useful as immunomodulating agents Norwich Eaton Pharmaceuticals, Inc. (US) 1986-07-16 EP claimed
US-4420548-A Electrophotographic member with hydrazone or ketazine compounds CANON KABUSHIKI KAISHA (JP) 1983-12-13 US claimed
US-4119776-A Vinyl phthalide color formers NCR CORPORATION (US) 1978-10-10 US claimed
US-4107428-A PHTHALIDE COMPOUNDS NCR CORPORATION (US) 1978-08-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167101-A1 NOVEL INHIBITORS OF HISTONE ACETYLTRANSFERASE P300/CBP FOR CANCER THERAPY EP300, CREBBP, HDAC1 ALDH1A1 1240/4885MAPT 2985/4885L3MBTL1 659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.