Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25049226 | 0.77 | DGAT1 (0.34) | DGAT1MAPTCLK4ATRATRIP | |
| SCHEMBL759979 | 0.77 | CYP11B2 (0.43) | DGAT1CYP19A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL29806073 | 0.75 | CYP2C19 (0.40) | CYP2A6DGAT1CYP19A1CYP3A4CYP2D6 | |
| SCHEMBL2608747 | 0.74 | MAPT (0.37) | CYP2A6DGAT1CYP19A1CYP3A4CYP2D6 | |
| SCHEMBL25049222 | 0.74 | DGAT1 (0.33) | DGAT1ATRATRIP | |
| SCHEMBL25049228 | 0.74 | DGAT1 (0.33) | DGAT1MAPTATRATRIP | |
| SCHEMBL2608751 | 0.74 | CYP2C19 (0.36) | CYP2A6DGAT1CYP19A1CYP3A4CYP2D6 | |
| SCHEMBL25049227 | 0.74 | MAPT (0.33) | DGAT1MAPTATRATRIP | |
| SCHEMBL30405652 | 0.73 | MERTK (0.45) | CYP2A6DGAT1CYP19A1CYP3A4CYP2D6 | |
| SCHEMBL29746608 | 0.73 | MAPT (0.41) | DGAT1NPC1MAPTATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742046-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024002-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |