SCHEMBL1469967

SCHEMBL1469967

FC(F)(F)c1cccc(B(c2cccc(C(F)(F)F)c2)c2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.69
TSHR P16473 2/20 0.52
MAPK1 P28482 1/20 0.52
HTR3E A5X5Y0 1/20 0.47
HTR3B O95264 1/20 0.47
HTR3A P46098 1/20 0.47
HTR3D Q70Z44 1/20 0.47
HTR3C Q8WXA8 1/20 0.47
CES2 O00748 1/20 0.47
ALDH1A1 P00352 2/20 0.46
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
MMP1 P03956 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP8 P22894 1/20 0.44
MMP13 P45452 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44
IDO1 P14902 2/20 0.42
TRPV6 Q9H1D0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8852080 0.82 MGLL (0.64) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL4995 0.82 MGLL (1.00) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL8852300 0.82 MGLL (0.64) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL62723 0.79 TSHR (0.67) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL15976469 0.77 MGLL (0.58) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL30553105 0.76 TSHR (0.64) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL30252943 0.76 TSHR (0.64) MGLLTSHRMAPK1HTR3EHTR3B
Fluoride SCHEMBL30661872 0.76 TSHR (0.64) MGLLTSHRMAPK1HTR3EHTR3B
Benzene SCHEMBL8568955 0.76 TSHR (0.67) MGLLTSHRMAPK1HTR3EHTR3B
SCHEMBL28126330 0.76 TSHR (0.64) MGLLTSHRMAPK1HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1935922-B1 Method for manufacturing SiOC-linked, linear polydimethyl siloxane polyoxyalkyl block copolymers and their application EVONIK GOLDSCHMIDT GMBH (DE) 2013-05-08 EP claimed
EP-1935920-B1 Method for converting polyorganosiloxanes and their application EVONIK GOLDSCHMIDT GMBH (DE) 2011-11-02 EP claimed
US-7825205-B2 Process for the preparation of SiOC-linked, linear polydimethylsiloxane-polyoxyalkylene block copolymers and their use EVONIK GOLDSCHMIDT GMBH (DE) 2010-11-02 US claimed
US-7825206-B2 Process for reacting polyorganosiloxanes and their use EVONIK GOLDSCHMIDT GMBH (DE) 2010-11-02 US claimed
EP-1544232-B1 Polysiloxanes with SiOC-bounded (meth)acrylic acid ester groups, process for their preparation and their use as irradiation-curable release coating EVONIK GOLDSCHMIDT GMBH (DE) 2010-03-03 EP claimed
US-20080153992-A1 Process for the preparation of SiOC-linked, linear polydimethylsiloxane-polyoxyalkylene block copolymers and their use EVONIK GOLDSCHMIDT GMBH (DE) 2008-06-26 US claimed
US-20080153934-A1 Process for reacting polyorganosiloxanes and their use EVONIK GOLDSCHMIDT GMBH (DE) 2008-06-26 US claimed
EP-1935922-A2 Method for manufacturing SiOC-linked, linear polydimethyl siloxane polyoxyalkyl block copolymers and their application Evonik Goldschmidt GmbH (DE) 2008-06-25 EP claimed
US-20070299231-A1 POLYSILOXANES CONTAINING (METH)ACRYLIC ESTER GROUPS ATTACHED VIA SiOC GROUPS, PROCESSES FOR PREPARING THEM AND THEIR USE AS A RADIATION-CURABLE ADHESIVE COATING GOLDSCHMIDT GMBH (DE) 2007-12-27 US claimed
EP-1460099-B1 Process for modifying polysiloxanes GOLDSCHMIDT GMBH (DE) 2006-06-21 EP claimed
US-20060041097-A1 Catalytic system for the dehydrogenative condensation of polyorganosiloxanes with alcohols and a process for preparing organically modified polyorganosiloxanes EVONIK DEGUSSA GMBH (DE) 2006-02-23 US claimed
EP-1627892-A1 Catalytic system for the dehyrogenative condensation of polyorganosiloxanes with alcohols and process for the preparation of organically modified polyorganosiloxanes Goldschmidt GmbH (DE) 2006-02-22 EP claimed
US-20050136269-A1 Polysiloxanes containing (meth)acrylic ester groups attached via SiOC groups, processes for preparing them and their use as a radiation-curable abhesive coating EVONIK GOLDSCHMIDT GMBH (DE) 2005-06-23 US claimed
US-20040186260-A1 Process for the reaction of polyorganosiloxanes GOLDSCHMIDT GMBH (DE) 2004-09-23 US claimed
EP-4594394-A1 METHOD FOR PRODUCING SIOC-LINKED, LINEAR POLYDIALKYLSILOXANE-POLYETHER BLOCK COPOLYMERS AND THE USE THEREOF Evonik Operations GmbH (DE) 2025-08-06 EP disclosed
WO-2024068268-A1 METHOD FOR PRODUCING SIOC-LINKED, LINEAR POLYDIALKYLSILOXANE-POLYETHER BLOCK COPOLYMERS AND THE USE THEREOF EVONIK OPERATIONS GMBH (DE) 2024-04-04 WO disclosed
US-20220315709-A1 PROCESS FOR PRODUCING SIOC-BONDED, LINEAR POLYDIALKYLSILOXANE-POLYETHER BLOCK COPOLYMERS AND USE THEREOF EVONIK OPERATIONS GMBH (DE) 2022-10-06 US disclosed
US-5594079-A COORDINATION CATALYST CONTAINING BORON, STEREOREGULAR POLYPROPYLENE TOSOH CORPORATION (JP) 1997-01-14 US disclosed
WO-1996023010-A2 α-OLEFINS AND OLEFIN POLYMERS AND PROCESSES THEREFOR E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-08-01 WO disclosed
EP-0582278-A2 Method for producing a polyolefin TOSOH CORPORATION (JP) 1994-02-09 EP disclosed