Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17708617 | 0.92 | NOS1 (0.44) | NOS1NOS3NOS2KDM4EALDH1A1 | |
| SCHEMBL17708666 | 0.89 | NOS1 (0.46) | NOS1NOS3NOS2KDM4EALDH1A1 | |
| SCHEMBL7737894 | 0.83 | NOS1 (0.43) | NOS1NOS3NOS2 | |
| SCHEMBL2834751 | 0.83 | NOS1 (0.44) | NOS1NOS3NOS2 | |
| SCHEMBL17708654 | 0.82 | NOS2 (0.71) | NOS1NOS3NOS2 | |
| SCHEMBL22566645 | 0.82 | NOS2 (0.42) | NOS1NOS3NOS2KDM4EALDH1A1 | |
| SCHEMBL2836244 | 0.82 | NOS1 (0.59) | NOS1NOS3NOS2 | |
| SCHEMBL17708541 | 0.81 | NOS2 (0.72) | NOS1NOS3NOS2 | |
| SCHEMBL2836248 | 0.81 | NOS1 (0.57) | NOS1NOS3NOS2 | |
| SCHEMBL17708640 | 0.80 | NOS2 (0.50) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NOS2, NOS1, NOS3 | NOS1 2/4885NOS3 3/4885NOS2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.