SCHEMBL14701779

SCHEMBL14701779

CCC(C)(C)Oc1ccc(C2(c3ccc(OC(=O)C(C)C)c(C)c3)c3ccccc3Cc3ccccc32)cc1C

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
NPSR1 Q6W5P4 1/20 0.33
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
ATM Q13315 1/20 0.33
ALOX15 P16050 1/20 0.32
PPARA Q07869 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
ELANE P08246 1/20 0.31
LMNA P02545 1/20 0.31
ADRB2 P07550 1/20 0.30
ADRA2A P08913 1/20 0.30
DRD2 P14416 1/20 0.30
ADRA2C P18825 1/20 0.30
DRD1 P21728 1/20 0.30
ADRA1A P35348 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14192279 0.89 ESR1 (0.43) KMT2AMEN1NPSR1POLBAPEX1
SCHEMBL10066097 0.82 ESR1 (0.41) KMT2AMEN1NPSR1POLBAPEX1
SCHEMBL14701778 0.79 ESR1 (0.44) NPSR1ESR1ESR2ELANELMNA
SCHEMBL823275 0.79 ESR1 (0.40) KMT2AMEN1NPSR1POLBAPEX1
SCHEMBL18648958 0.78 ESR1 (0.45) KMT2AMEN1NPSR1POLBESR1
SCHEMBL13758548 0.76 VDR (0.41) KMT2AMEN1ALOX15ADRB2ADRA2A
SCHEMBL18648920 0.74 ESR1 (0.41) ESR1ESR2ELANE
SCHEMBL14700590 0.73 CHRM5 (0.40) POLBESR1ESR2
SCHEMBL10065614 0.72 ESR1 (0.40) ESR1ESR2ELANE
SCHEMBL19750309 0.70 ESR1 (0.43) KMT2AMEN1NPSR1POLBESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130040234-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, MANUFACTURING METHOD THEREFOR AND ELECTROPHOTOGRAPHIC DEVICE FUJI ELECTRIC CO., LTD. (JP) 2013-02-14 US disclosed