Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154118 | 0.78 | SMN1; SMN2 (0.56) | ALDH1A1KDM4EPOLBLMNAMAPT | |
| SCHEMBL12072357 | 0.75 | GPR3 (0.40) | L3MBTL1ALDH1A1GPR3RXFP1POLB | |
| SCHEMBL7427455 | 0.75 | LMNA (0.47) | L3MBTL1ALDH1A1KDM4EGPR3RXFP1 | |
| SCHEMBL4832538 | 0.73 | GAA (0.41) | L3MBTL1ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL1470347 | 0.72 | GPR3 (0.38) | L3MBTL1ALDH1A1KDM4EGPR3RXFP1 | |
| SCHEMBL12335687 | 0.72 | EGLN1 (0.45) | L3MBTL1GPR3RXFP1LMNABBOX1 | |
| SCHEMBL5475190 | 0.72 | HSD17B10 (0.42) | L3MBTL1ALDH1A1KDM4EKMT2AGPR3 | |
| SCHEMBL31409925 | 0.72 | GPR3 (0.38) | L3MBTL1ALDH1A1KDM4EGPR3RXFP1 | |
| SCHEMBL19065035 | 0.72 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1KDM4EKMT2ACYP2A6 | |
| SCHEMBL29367505 | 0.71 | L3MBTL1 (0.67) | L3MBTL1ALDH1A1KDM4EKMT2AGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745024-B1 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NOVARTIS INT PHARM LTD (BM) | 2012-04-25 | — | — | EP | disclosed |
| US-7915288-B2 | 1-aryl-4-substituted isoquinolines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-03-29 | — | — | US | disclosed |
| EP-1745024-A4 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20070249665-A1 | 1-aryl-4-substituted isoquinolines | NEUROGEN CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| CN-1980895-A | 1-aryl-4-substituted isoquinolines | NEUROGEN CORP (US) | 2007-06-13 | — | — | CN | disclosed |
| EP-1745024-A1 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORPORATION (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005110991-A1 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249665-A1 | 1-aryl-4-substituted isoquinolines | C3AR1, C5AR1, C5AR2 | L3MBTL1 3234/4885ALDH1A1 1164/4885KDM4E 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.