Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14141462 | 0.84 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL8231474 | 0.84 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL17549781 | 0.81 | HDAC1 (0.77) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL25561421 | 0.78 | HDAC1 (0.51) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| Trichostatin SCHEMBL446806 | 0.69 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| Trichostatin SCHEMBL446807 | 0.69 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| Trichostatin SCHEMBL19886 | 0.69 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| Trichostatin SCHEMBL675951 | 0.69 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| Trichostatin SCHEMBL16380793 | 0.69 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL8089729 | 0.68 | HDAC3 (0.40) | HDAC1HDAC6HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040998-A1 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040998-A1 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | HDAC1 1/4885HDAC6 3/4885HDAC3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.